The Dutchman has admitted he needs to increase his first team minutes to secure a place in Holland's World Cup squad this summer.
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Ake rejected an offer from West Ham last week and now Palace have come forward hoping for better luck, says the Daily Mail.
However, City management may now be more reluctant to do business after Josko Gvardiol's leg fracture setback.
Also interested in Ake this month are Barcelona, though they are strictly insisting only on a loan arrangement.