For the fifth consecutive season, La Liga giants Madrid face off against Man City in a clash that is fit for the final or at least the latter stages of the competition.
Madrid enter the game without Eder Militao, Dani Carvajal, and Trent Alexander-Arnold and will be looking to bounce back from a 2-0 loss to Celta Vigo at the weekend.
Meanwhile, City beat Sunderland at the weekend but fell to Bayer Leverkusen in their last European game and will be seeking a vital 3 points to keep their hopes of qualifying for the next round alive.
Last season, Los Blancos knocked City out of the Champions League at the play-off stage, as Kylian Mbappe’s impressive hat-trick in the second leg secured a 6-3 aggregate win for the Spanish side.
Speaking to UEFA, Rodrygo opened up on the fixture, which he says hold a special place in his heart.
"It’s become a true Champions League derby. We play each other every year.
"Without a doubt it is one of our most challenging matches of the year. One side always makes things tough for the other. It’s grown into a real derby, an incredible, intense, back-and-forth contest.
“It’s a very special fixture that’s brought me great joy in the past, and I hope I get to see it happen many more times."
Madrid face Monaco (H), Benfica (A) in their final games, whilst City face Bodo/Glimt (A), Galatasaray (H) in what are tough games for both sides desperate for much needed victories.