Portugal need a win to be sure of qualifying for next summer's World Cup, but Al Nassr star is out of the game due to suspension after his red card in defeat to the Republic of Ireland this week.
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Should they draw and Hungary beat Ireland by more than three goals, though, they face needing to qualify through a playoff.
A Bola says Ronaldo will not be staying as a cheerleader for the tie and instead is returning to Saudi Arabia.
Al Nassr's next game is on November 23 against Al Khaleej.