Thanks to their two-point lead and superior goal difference over West Ham United, Spurs just need a draw to guarantee they will stay in the Premier League.
Tottenham led the head to head record across the last 20 meetings with 10 wins to Everton's two as they seek to dig deep and pull off a performance to save their skin after a dire campaign.
However, Spurs are still dealing with an injury crisis and have the likes of Xavi Simons (Knee Injury), Wilson Odobert (Knee Injury), Mohammed Kudus (Thigh Injury), Dejan Kulusevski (Knee Injury), Ben Davies (Ankle/Foot Injury), Diop Djed-Hotep Spence (Head/Face Injury).
Tottenham's bid for survival could be boosted by the return of Dominic Solanke (Thigh Injury) but the club are yet to make a decision on if he will return to the fold this weekend in what is the most important clash of the season.
Meanwhile, Cristian Romero (Knee Injury) will be in his native Argentina instead of at Spurs' final match of the campaign at home to Everton on Sunday as they battle to avoid relegation.
The defender is in a race against time to be fit for this summer's World Cup as he tries to recover from his knee injury. As Spurs captain he has been massively criticized over the past week as he abandons his side in a clash where his presence is much needed.