The Holland international is ready to leave United in January over a lack of minutes this season. Zirkzee has concerns about his place in Holland's World Cup squad should his club situation continue.
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As such, Zirkzee is eyeing a return to Italy, where the former Bologna striker is on the radar of Roma.
The Sun says Roma are keen to setup a loan deal in January, with finances tight at the Giallorossi.
Roma coach Gian Piero Gasperini is a fan of Zirkzee, though Premier League competition could arrive midseason from West Ham, which are also watching developments.