United manager Ruben Amorim has named new signing Benjamin Sesko on the bench, while Altay Bayindir starts between the posts with fellow goalkeeper Andre Onana not making the matchday squad.
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Meanwhile, Arsenal boss Mikel Arteta will start with Viktor Gyokeres leading the attack. There is also a debut for Martin Zubimendi in midfield.
Manchester United XI: Bayindir, De Light, Yoro, Shaw, Dalot, Fernandes, Casemiro, Dorgu, Mount, Mbeumo, Cunha
Subs: Heaton, Maguire, Zirkzee, Amad, Ugarte, Heaven, Sesko, Fredricson, Mainoo
Arsenal XI: Raya, White, Saliba, Gabriel, Calafiori, Zubimendi, Rice, Odegaard, Martinelli, Saka, Gyokeres
Subs: Arrizabalaga, Mosquera, Merino, Nwaneri, Madueke, Havertz, Lewis-Skelly, Timber, Trossard