Sky Sports says United are aiming to raise over £100m from player sales at the end of this season.
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Marcus Rashford is expected to leave with Barcelona holdng a £26m option for his permanent transfer.
Rasmus Höjlund will be sold in all probability. Napoli has a mandatory purchase option of £38m.
Manchester United can also sell Manuel Ugarte, Joshua Zirkzee and André Onana this summer. Onana is currently on loan with Trabzonspor.
Meanwhile, it is already clear that Casemiro will leave as his contract runs down.
Jadon Sancho and Tyrell Malacia also expected to leave as Bosman transfers this summer