Already guaranteed to finish first or second in the table but must grab at least a draw to guarantee finishing top of the table in what has been an incredible European campaign so far.
The Gunners have picked up 21 points from 21 on offer to confirm a spot in the last 16 with a game to spare and manager Mikel Arteta may rotate his side to save his players for the game against Leeds United at the weekend.
However, Arteta will miss a number of players for the game which makes rotation difficult as the Spanish head coach turns towards youth player to replace the likes of Declan Rice who is suspended.
In defense, Arsenal will miss William Saliba (unknown) and Jurrien Timber (unknown) for the clash with Arteta speaking on the pair who could return early next month.
"They have some niggles, and it's a good opportunity now that we make a different kind of work with them to get them in the best possible conditions that we can offer them."
In midfield, the Gunners have lost both Max Dowman (Ankle/Foot Injury) and Mikel Merino who, much like Rice, will sit out the fixture after receiving his third yellow card of the competition, earned in stoppage time against Inter Milan.
Kairat have collected just a solitary point in the 2025-26 league phase and should not pose much of a threat to Arsenal who can cruise against the Kazakhstani side despite their injuries as they look towards the next round.