The Reds head to RAMS Park for the first leg of their round of 16 tie as they seek revenge for their 1-0 loss back in September following a Victor Osimhen goal.
Galatasaray have scored at least three goals in eight of their last 13 matches at RAMS Park in Europe and will be hoping for another upset.
Liverpool have won just one of five previous games against the Turks in the Champions League, and have never beaten them away in what is a worrying statistic.
Manager Arne Slot picked his side for the early kick off as team news was announced on Tuesday afternoon as he makes a number of notable changes.
This includes dropping Cody Gakpo, a player widely criticized in recent weeks in favour of Florian Wirtz who returns after suffering a lower back injury in recent weeks.
Alongside him, Mohamed Salah, Hugo Ekitike and Dominik Szoboszlai all start in the club’s dominant attack whilst Joe Gomez replaces Jeremie Frimpong at right back as Slot rotates his side.
Liverpool have conceded more goals in their three most recent games (five) than they did in their prior six matches (three) and will attempt to secure a win or draw away from home before the second leg at Anfield.