A 0-0 draw with Curacao on Tuesday (November 18) ended McClaren and Jamaica’s hopes of qualifying for next year’s World Cup automatically.
The 64-year-old took charge of Jamaica in 2024 and guided them through a qualification campaign that represented their best hopes of reaching the tournament proper since 1998.
Jamaica still have hope of qualifying via the intercontinental play-offs but will have to beat either DR Congo or Iraq.
“Leading this team has been one of the greatest honours of my career,” McClaren said.
“But football is a results business and tonight we have fallen short of our goal, which was to qualify from this group.
“It is the responsibility of the leader to step forward, take accountability and make decisions in the best interests of the team.
“After deep reflection and an honest assessment of where we are and where we need to go, I have decided to step down as head coach of the Jamaican national team.
“Sometimes the best thing a leader can do is to recognise when a fresh voice, new energy and a different perspective is required to move this team forward.
“I thank you, Jamaica. I will be forever grateful to have led the Reggae Boyz, really has been an honour, respect and one love to you all.”