At an elevation of 2,241 meters (7,352 ft) above sea level, the Azteca is infamous for its brutal conditions which leave world class players gasping for breath if they have not adapted properly.
Mexico have lost just twice at the Azteca in a staggering 89 matches and look unbeatable at the World Cup this summer as they fully embrace their home advantage.
Much has been said about the altitude problem England face, a problem which cannot be solved in such a small amount of time.
The Azteca is a disgrace
Speaking on the issues, Collymore spoke with BetGoodwin about how he believes the venue is a disgrace and makes the tie completely unfair.
“It’s wrong that Mexico have been permitted such a big physical advantage,” he said.
“I think FIFA and Gianni Infantino need to sit down with the other associations and find a way to make these tournaments fairer. Canada, for example, are a co-host but have had to play across the border in Seattle, while Mexico have been able to basically stay at the Azteca, where they've lost only twice in over 80 matches.
“We all know the physiological advantage of playing at altitude is very real. That was known well in advance, so I think it's grossly unfair that one team can have such a significant physical advantage in what's supposed to be a level playing field.
“For me, the whole hosting system needs looking at. England, with arguably the biggest domestic league in world football, haven't hosted a World Cup in the modern television era, while Mexico have now had three.
“So yes, I think it's absolutely wrong that one country can have such a clear physiological advantage over another.”
England may not be able to catch their breath on Monday as a World Cup exit looks likely for the side who face their toughest challenge yet against a ruthless Mexico side.