Reina, now 42, says Friday night's clash with Inter Milan will be his last.
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"A very beautiful career is coming to an end, a very full life," Reina told Movistar+. "I feel very fortunate for what I’ve experienced.
"It’s been many years… I didn’t expect it, but I think the time has come and I feel like bringing it to a close here."
Reina moved to Como last summer from Villarreal. Among the clubs he played for have been Liverpool, AC Milan, Aston Villa and Napoli.