The star forward missed an early penalty and limped off injured, yet his teammates fought back to snatch all three points, reclaiming top spot from Al-Ahli.
Al-Nassr were handed an early penalty after minimal contact on Mohamed Simakan in the box, but the Portugal legend sent his spot-kick wide.
Al-Fayha seemed in control after an own goal by Abdulelah Al-Amri just before half-time gave Al-Nassr the lead.
The hosts resisted wave after wave of attacks, holding out until Kingsley Coman and Sadio Mane broke through.
Joao Felix then rifled in a late goal off the post, with the ball bouncing in via goalkeeper Orlando Mosquera, before Abdullah Al-Hamdan added a fourth to complete a dramatic comeback, restoring Al-Nassr to the summit.
