Newcastle are looking to sign a new striker this summer following the shock transfer request from star man Alexander Isak.
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Howe’s side had a £25 million bid turned down by Brentford for striker Wissa, 28, with the West London club reluctant to sell this summer.
According to Sky Sports, the striker was left ‘disappointed’ by the decision to turn the bid down and has no intention of returning to Brentford.
The Magpies are understood to still be interested in bringing Wissa to St James’ Park but will now assess other options.