Defeat for Liverpool could further bring Slot's position as Reds manager into question.
Nuno said ahead of the showdown: "We know they are a very good team, and in football it’s about what happens on the day, so the history of the teams and their recent form isn’t important.
"I look at Liverpool individually for our game - I don’t make major analysis of their form. I’m focused on how we can compete against them and the challenges we have ahead.
"What we expect is the champions of the Premier League. They have incredibly talented players, who are capable of doing good things, so we have to be ready.
"There are always questions about every manager in the Premier League and around the world, raised by the press. It’s part of the industry.
"I will salute Arne before the game as normal. But my focus is on myself, my team and on us getting the result we want.
"We can’t predict how they’re going to line up, especially teams like Liverpool who are competing in Europe in midweek. But we know that no matter what, Liverpool will have immense quality all over the pitch, so we will have to be ready for that."