Isak, 26, secured his British record transfer to Liverpool on transfer deadline day having gone on strike throughout the summer transfer window.
Newcastle have since signed Nick Woltemade and Yoane Wissa as replacement for the talismanic Swedish striker.
Howe’s side have struggled since the start of the season, sitting down in 13th with just six points from their opening five games.
Speaking after their 0-0 draw with Bournemouth on Sunday, Howe admitted that his side are still adapting to life without Isak.
Howe said: “It’s three 0-0s away from home for us, which is really uncommon with our attacking style. I think just naturally we’re going to be a different team attacking-wise this year without Alex."
When asked about how his replacement, Woltemade, performed, Howe said: “I thought Nick played really well today.”
“I thought he was very effective with his footwork and his link play.
“But we just need to know and get used to him and his style more and get more runners off him because he’s very good in that respect.
“I’m hopeful we’re evolving to a different team, hopefully a better team, but it may take a bit of time.”