Tottenham are probing the issue after Bissouma was seen allegedly taking nitrous oxide.
The midfielder has been the victim of multiple break-ins in London this year.
He told The Sun: "I am sorry.
"This (latest break-in) broke something in me I didn't even know I could break. I apologise to the fans. The trauma added to my life - fear, panic, depression and paranoia."
Addressing the recent accusations, he continued: "I feel really bad about it. I have to apologise. When the picture came out it affected me and everyone, especially my family.
"When my Dad saw it, he was panicking because he didn't feel good. I tried to make him understand that it's a hard image, but not who I am. I know it's not good for me, for my image, because I'm a professional football player."