Newcastle’s Champions League adventure came to an abrupt end with a heavy 8-3 aggregate defeat to Barcelona.
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Currently sitting in ninth place in the Premier League, qualification for next season’s tournament is looking unlikely.
Several reports have since suggested that Guimaraes, 28, could look to leave in the summer, with Man United interested.
Speaking to reporters ahead of their game against rivals Sunderland on Sunday (March 22), Howe addressed the rumours.
"To say our captain is in discussions with another club is totally disrespectful to Bruno more than anything else, he is totally committed here," Howe explained.
"Bruno’s our captain, he’s fully committed, he’s injured at the moment, his only focus is coming back to fitness."