Both teams enter the game in different form, with Arsenal being on the back of a 2-1 loss to Bournemouth and City confidently heading to the Emirates after a 3-0 win over Chelsea last weekend.
However, Arsenal remain top of the Premier League table, with a six-point gap over Sunday’s hosts, who have a game in hand.
City were victorious in the last meeting between the pair less than four weeks ago, winning 2-0 in the Carabao Cup final and will aim to pull off a similar result this time around in what is a crucial game for the title race.
Arsenal, who are under immense pressure, will be without 6 key players for the clash as manager Mikel Arteta rotates his side following the 0-0 draw against Sporting this weekend.
Jurrien Timber (Groin/Hip/Pelvic Injury), Mikel Merino (Ankle/Foot Injury), Bukayo Saka (Calf/Shin/Heel Injury), Martin Odegaard (Knee Injury), Riccardo Calafiori (Other) and Noni Madueke (Knee).
Meanwhile, City boss Pep Guardiola won’t have 3 players at his disposal after a break in midweek due to being knocked out the Champions League earlier this season.
Josko Gvardiol (Calf/Shin/Heel Injury), Ruben Dias (Thigh Injury) and John Stones (Calf/Shin/Heel Injury).
Thankfully for City, Guardiola revealed starlet Nico O'Reilly will be fit to face Arsenal after suffering an injury scare in recent weeks which is a boost for him but a major worry for Arsenal after he scored a brace in the EFL Cup final.