Leverkusen visit the Emirates on Tuesday night as the Bundesliga side try to snatch a shock result in North London after a 1-1 result in the first leg.
Just one of Arsenal's last 22 UEFA competition games at the Emirates has seen the Gunners fall to defeat, and the Premier League leaders will be filled with confidence heading into the clash following a 2-0 win over Everton at the weekend.
Arsenal have scored more goals from set-pieces than any other team in the Premier League this season, netting 21 times from corners, throw-ins and free kicks.
They will aim to add to their impressive set piece numbers this week despite missing the likes of Jurrien Timber (anke / foot), Martin Odegaard (knee) and Mikel Merino (foot) as manager Mikel Arteta rotates his side who have more than enough quality to bypass Leverkusen.
The Bundesliga side are without 5 players in Mark Flekken (ligament), Loïc Badé (hamstring), Lucas Vázquez (calf) Arthur (Syndesmotic ligament tear) and Edmond Tapsoba who is suspended for the clash.
Arsenal have scored in all nine of their UCL games in 25/26, and at home they've won every game, scoring 12 goals in those four matches and conceding just three.
Leverkusen are winless in three competitive matches with Arsenal in what will be a tough test for the German side who could stun the football world with a rare victory.