Seeking to win a fourth Premier League game in a row under interim boss Michael Carrick, United host Spurs at Old Trafford as they aim to maintain their position within the top 4.
Spurs meanwhile, look to build on a second half comeback against Manchester City on what is an 4 game unbeaten run. Tottenham sit in 14th in the Premier League table thanks to manager Thomas Frank, nine points clear of the relegation zone.
However, the side do have a plethora of injuries heading into the game, including Kevin Danso (ankle), Lucas Bergvall (ankle), Ben Davies (foot) and Pedro Porro (thigh) in defence.
Frank will also miss out on the likes of James Maddison (Knee), Rodrigo Bentancur (Thigh), Mohamed Kudus (thigh), Richarlison (thigh), Dejan Kulusevski (knee) elsewhere in his squad as he deals with what is a bare-bones side.
Opponents Manchester United will also miss Patrick Dorgu (thigh), Mason Mount (other) and Matthijs de Ligt, who has been absent from the last 12 games across all competitions due to a lower back issue.
Anything other than a win for United could see Chelsea leap above them if they manage to beat bottom of the league Wolves this weekend, just hours after the Red Devils finish their game.
United lead the overall head-to-head record between these two sides, winning 96 of their previous 206 meetings as they aim to snatch 3 points in front of the home crowd.