The Daily Mail reports Real Madrid have the young England international on their radar.
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The Spanish giants' chief scout Juni Calafat is a big admirer and Real have had Wharton watched over the past 12 months.
Manchester City, Manchester United and Liverpool are also said to have the 21-year-old on their list of potential signings.
Crystal Palace are said to be asking for at least £70m to sell Wharton.
The midfielder has a contract that runs until the summer of 2029.