The France U21 has attracted interest from Europe's biggest clubs this year.
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However, BBC Sport says Newcastle are now making a serious move for Ekitike, which could involve a club record bid for the striker.
Newcastle insiders say they're willing to go above £70m for the centre-forward, who would arrive to play alongside Alexander Isak and not to replace him.
Ekitike, 23, scored 15 goals and had eight assists last season. He is on a deal to 2029.
