The Manchester United defender struggled at times on the night was at fault for Bosnia's two goals.
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But Koeman insisted: "He himself realises that he was in the wrong position. This should not happen, but mistakes are part of football. I think it is unfair to make a big deal out of it."
De Ligt also said: "I think you know how I feel.. we won.. but then comes the individual part.. I should have done better at their second goal, and I know that. I don't really know what happened.. I should have cleared the ball but I kept having doubts during the play. It's just f****d."
He also added: "If this game is a missed opportunity for me? I don't know.. I just try to do my best."