Rodri is inside the final 18 months of his current deal and has talked up the prospect of returning home to Madrid over the past fortnight, stating "you can't turn down the best clubs in the world".
"There is not one player that will turn (down) the chance to play for (Real) Madrid," said Guardiola.
"Always my wish is that Rodri could stay as long as possible in this club because he is an incredible, top player but the life of everyone is everyone's."
Guardiola said Rodri has shown over time "how attached, how close he is" to City and his "contribution has been massive".
The manager confirmed he would "absolutely" not stand in the midfielder's way if he wanted to leave, adding: "The organisation of the club is above all of us - if one player is not happy they have to leave and continue the same always if they are happy - and I think he is happy.
"If he is not happy just knock on the door of the sporting director, accept an offer according to his incredible quality and after that he doesn't belong to the club - only himself.
"I know what the club wants. They informed me what they want from Rodri - it is to stay, stay, stay. I always had the positive with that but at the end I don't know."