Isak missed yesterday's 0-0 draw at Aston Villa as he attempts to force through a move to Liverpool.
Howe said: "We would like a resolution. I am talking about myself, I am sure the ownership, and the players. We need that clarity. You don’t need any distraction. But I am not in control of that. I think only one person really (Isak) can control that.
"This season, any season, every season, is going to be hard enough. You don't need any kind of distraction to swerve your thoughts, to unbalance what we're doing.
"I hope it's resolved quickly, because it's news around us all the time. The players have managed to shut that out and perform. We have to continue to do that."
During the draw at Villa Park, the away fans chanted "there’s only one greedy b******".
Howe said: "Whatever happens, I think the support has acted really well today because they supported the team, which is always my big ask, to support the team when we're playing. And they've done that unbelievably well in some difficult moments during the four years.
"And then if afterwards they want to say something, I think they're very free to do that."
Howe added: "Nothing has changed, but the door is well and truly open. But yeah, he has to decide what he wants to do."