The midfielder, who has recovered from ACL surgery he underwent a year ago, has been forced to the sidelines due to a hamstring issue.
"I don't think so for Villarreal - or Aston Villa (this weekend)," Guardiola said. "It's not long, but it's muscular and you have to be careful.
"We've tried so many times, we've tried to not take a risk, but we have not been able to (manage) that. So we will see."
Mateo Kovacic saw action for the win against Everton for the first time since May due to an achilles injury.
"Kovacic has a special quality with the ball to keep it," Guardiola added. "We cannot forget he’s come from surgery, a three or four-month injury. We need his quality back.
"I want Kovacic for 90 minutes, 90 minutes, 90 minutes. In the time, we’ll get it. But now I don't have that feeling that he's ready to play that. And it will not help him. But 20, 30 minutes… all the players we have, in different ways we can play, are extraordinary."