The midfielder was forced off during their comfortable victory over Alaves yesterday.
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Ikhomach struck before being stretchered off clutching his knee.
Villarreal coach Marcelino said afterwards: "We are worried.
"It is a knee injury and we will see the extent. I hope the diagnosis is as mild as possible. It seemed to hurt a little more on the side and I hope it is something lighter than we always think: the f***ing cruciate ligaments."
