The goalkeeper, 41, has spent the past two seasons with the Yellow Submarine and will leave when his contract expires this month.
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Reina posted to social media: "It is not easy to say goodbye to what has been, is and will be my home.
"Too many memories that I feel lucky to have shared in a club and with such special people.
"It's time to write a new point and then, I'm sure that our paths will cross again because life always takes you back to those places where you were happy.
"Now I need to find the site to help me write the last chapter, I feel very prepared and motivated to do it."