Natan was visibly concerned when forced off late into yesterday's derby defeat at Sevilla.
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However, there is hope the absence will be a matter of weeks and not months for the in-form Brazilian defender.
Betis coach Manuel Pellegrini said afterwards: “The doctor saw him, he has a sprain in his knee, we will see what degree it is and if he has any other injuries.
"For now it seems like a sprain, but he will be checked during the week.”