The Frenchman has previously been linked with Atlético Madrid and Liverpool.
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Foot Mercato says Barcelona have now made an enquiry for Simakan - who is tied to RB Leipzig until the summer of 2027.
Barcelona appreciate Simakan as he can play both at centre-back and right-back.
The player has a buy-out clause in his contract that stands at €50m.
Barca see Simaken as a replacement for wantaway veteran Inigo Martinez, who is wanted by Al Ittihad.
