Police officers in riot gear were deployed in the city centre to put a stop to any violent skirmishes that broke out between both sets of fans in what was a violent scuffle.
Two officers, one from the Federal Police and one from the State Police, sustained minor injuries during clashes according to the BBC as fans reacted to the clash on social media over the past few days.
Supporters of both clubs attacked German police, mainly by throwing objects at them during the chaos. The police have now released statement after it was reported that multiple fans had been arrested.
"At approximately 20:00 (19:00 BST), around 300 Rayo Vallecano fans, considered to be at high risk of hooliganism, were gathered in the city centre," read a statement from Saxon State Police.
“Bottles, beer glasses, and pub furniture were thrown at each other. Physical altercations also occurred," added the police statement.
"Officers on the scene immediately intervened and separated the two groups of fans, checked the identities of more than 300 people, and issued dispersal orders.
"Known troublemakers from Crystal Palace moved to the area of the Penguin Ice Bar and approximately 60 individuals provoked passing Spanish fans and were surrounded by federal police."
Both clubs are seeking their first major European trophy this week as tensions rise between both sets of supporters. Palace boss Oliver Glasner is also taking charge of his final game in charge, as the club also look to qualify for the Europa League with victory.