Oliver Glasner's side failed to win any of their four top-flight matches succeeding their win over Shakhtar Donetsk in the semi-finals as they seek to turn their form around in the final.
Palace are favourites to Lift the Trophy in Leipzig in what would be their first European trophy and the last piece of silverware before Glasner departs this summer.
Both sides enter the game on the back of different results as Palace lost 2-1 to Arsenal, while the La Liga side ended their domestic campaign with a 2-1 triumph over Deportivo Alaves.
Ahead of the clash, the Eagles are without Edward Nketiah (Thigh Injury), Christopher Richards (Ankle/Foot Injury), Borna Sosa (Other) and Cheick Doucoure (Other).
Most importantly, Adam Wharton (Ankle/Foot Injury) is also a doubt as Palace continue to sweat over his fitness.
Glasner's decision to bring Adam Wharton on at half-time against Arsenal backfired, as the England international lasted just 16 minutes before being withdrawn with an ankle injury.
However, he was spotted back in training ahead of the final as reports remain hopeful that he will be back in the starting line up for the final this week.
Having lifted the FA Cup and the Community Shield, Glasner would establish himself as a club legend if he claimed a European trophy this week before he departs later this year.