Duran is set to undergo a medical with Al-Nassr for a transfer worth €77m.
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He was an unused substitute in Villa's 4-2 victory over Celtic, which secured their place in the Champions League last-16.
TNT Sports reported that Duran was seen handing out gifts in the tunnel after the match.
Asked about the matter, Villa boss Unai Emery said: "I don't know if Jhon Duran is leaving.
"But if he is, it is good news for us because he is leaving because it is good money. “It is for the club, the players and the team. I don't know if he will leave or not. Watkins is our striker."