The Argentine is in Madrid this week and was a guest of Atletico Madrid for last night's Champions League win against Tottenham.
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With Alvaro Arbeloa losing confidence inside the Real Madrid board room, Pochettino has been mentioned as a candidate for the job.
And the Argentine refused to rule out replacing Arbeloa.
"In due time. In football, it is always the timing that determines (what happens). Football takes you where it wants, not where you want," Pochettino tells El Chiringuito.
Pochettino's contract with the US Soccer Federation expires after the World Cup this summer.