Karl, 18, is in the Germany squad for the first time for the friendlies against Switzerland and Ghana this coming week.
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Nagelsmann told BILD: "I expect him to bring his youthful energy and playful into the field with the national team.
"He prefers to play centrally, but we also plan to use him on the right edge. However, I do not want to put pressure on him to deliver miracles.
"He has to contribute what a young player stands for: Play freely and with his heart - just as he has done in FC Bavaria."