The manager had indicated that the African was expected to return to the matchday squad after sitting out the UEFA Super Cup on Wednesday.
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However, when the starting XI and substitutes were revealed for the Premier League opener against the Clarets, the midfielder’s absence was a notable surprise.
"Unfortunately, (Yves) got injured in training yesterday," Frank told club website
"We need to look into how (bad) it is."
A Richarlison brace and a goal from Brennan Johnson secured Spurs a convincing 3-0 home victory in London.